Sari, Arina Dery Puspita Primary Author mixed material bibliography Surabaya Fakultas Farmasi UNAIR 2007 monographic id Indonesia

Text

xi; 53p.; 29,5cm The objective of this study was to determine the effect of HPMC 2910 3cP concentration as tablet binder on physical performance of green tea extract lozenges with manitol base especially hardness, friability, and dissolving time. The tablets were prepared by wet granulation method using three different concentrations of HPMC 2910 30, 1 % ( F 2 ), 3 % ( F 3 ), and 5 % ( F 4 ). The granules had good moisture content value but not acceptable result on flow properties. The granules were compresed with a pressure of 2 tons for 3 seconds and the diameter of the die was 13 mm. The tablets were evaluated for hardness, friability, and dissolving time. All tablets formulation showed acceptable results on hardness and friability test, but just F1 and F2 were acceptable on the dissolving time test. Statistical analysis using SPSS Version 11.5 suggested that increasing of HPMC 2910 3cP concentration would increase hardness, less friability, and increased dissolving time of the green tea extract lozenges. The most optimal concentration of HPMC 2910 3cP was 1 %. GRANNULATION TABLETTING 6B.S Sar f PERPUSTAKAAN FAKULTAS FARMASI - UNIVERSITAS HANG TUAH Jl. Arief Rachman Hakim 150 , Surabaya 60111 Telp: (031) 5945864, 5945894 Fax : (031) 5946261 , Web. www.hangtuah.ac.id 6B.S Sar f FARM90-6B.S-2015 Perpus Farmasi (Rak Skripsi) 6B.S Sar f skripsi_Arina_Dewi_Puspita_Sari.jpg.jpg 388 2015-10-19 09:01:51 2015-10-19 09:03:25 machine generated